Modeling the decay of hotspot motifs in broadly neutralizing antibody lineages
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چکیده
10:30 11:00 Keneth Hoehn University of Oxford Modeling the decay of hotspot motifs in broadly neutralizing antibody lineages 11:00 11:30 Joe O'Reilly University of Bristol The Mk Model for Total Evidence Dating: Fit for Purpose? 11:30 12:00 Jose Barba-Monotya University College London Constraining uncertainty in timescale of angiosperm evolution and the veracity of a Cretaceous Terrestrial Revolution
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A Phylogenetic Codon Substitution Model for Antibody Lineages
Phylogenetic methods have shown promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, the mutational process that generates these lineages, somatic hypermutation, is biased by hotspot motifs which violates important assumptions in most phylogenetic substitution models. Here, we develop a modified GY94-type substitution model that partially accounts...
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Phylogenetic methods have shown great promise in understanding the development of broadly neutralizing antibody lineages (bNAbs). However, mutational process for generating these lineages – somatic hypermutation (SHM) – is biased by hotspot motifs, which violates important assumptions in most phylogenetic substitution models. Here, we develop a modified GY94-type substitution model which partia...
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تاریخ انتشار 2016